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1

Pharmacological Levels of Withaferin A (Withania somnifera) Trigger Clinically Relevant Anticancer Effects Specific to Triple Negative Breast Cancer Cells

Szarc vel Szic, Katarzyna, Op de Beeck, Ken, Ratman, Dariusz, Wouters, An, Beck, Ilse M., Declerck, Ken, Heyninck, Karen, Fransen, Erik, Bracke, Marc, De Bosscher, Karolien, Lardon, Filip, Van Camp, G

Journal:

Year:

2014

Language:

english

File:

PDF, 3.03 MB

english, 2014

2

Polyphenols in Human Health and Disease || Cancer Chemoprevention by Dietary Polyphenols

Heyninck, Karen

Year:

2014

Language:

english

File:

PDF, 1.66 MB

english, 2014

3

Adenoviral gene transfer of ABIN-1 protects mice from TNF/galactosamine-induced acute liver failure and lethality

Andy Wullaert, Ben Wielockx, Sofie Van Huffel, Veerle Bogaert, Bart De Geest, Peggy Papeleu, Peter Schotte, Karim El Bakkouri, Karen Heyninck, Claude Libert, Rudi Beyaert

Journal:

Year:

2005

Language:

english

File:

PDF, 355 KB

english, 2005

4

Inflammatory cardiac valvulitis in TAX1BP1-deficient mice through selective NF-κB activation

Peloponese, Jean-Marie, Verstrepen, Lynn, Zapart, Grzegorz, Ikeda, Fumiyo, Smith, C Dahlem, Starost, Matthew F, Yedavalli, Venkat, Heyninck, Karen, Dikic, Ivan, Iha, Hidekatsu

Journal:

The EMBO Journal

Year:

2008

Language:

english

File:

PDF, 748 KB

english, 2008

5

T cell antigen receptor stimulation induces MALT1 paracaspase–mediated cleavage of the NF-κB inhibitor A20

Coornaert, Beatrice, Baens, Mathijs, Heyninck, Karen, Bekaert, Tine, Haegman, Mira, Staal, Jens, Sun, Lijun, Chen, Zhijian J, Marynen, Peter, Beyaert, Rudi

Journal:

Nature Immunology

Year:

2008

Language:

english

File:

PDF, 389 KB

english, 2008

6

The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases

De Valck, Dirk, Jin, Dong-Yan, Heyninck, Karen, Van de Craen, Marc, Contreras, Roland, Fiers, Walter, Jeang, Kuan-Teh, Beyaert, Rudi

Journal:

Year:

1999

Language:

english

File:

PDF, 478 KB

english, 1999

7

Mechanisms of crosstalk between TNF-induced NF-κB and JNK activation in hepatocytes

Andy Wullaert, Karen Heyninck, Rudi Beyaert

Journal:

Biochemical Pharmacology

Year:

2006

Language:

english

File:

PDF, 498 KB

english, 2006

8

A20 inhibits NF-κB activation by dual ubiquitin-editing functions

Karen Heyninck, Rudi Beyaert

Journal:

Trends in Biochemical Sciences

Year:

2005

Language:

english

File:

PDF, 1.52 MB

english, 2005

9

A20 and A20-binding proteins as cellular inhibitors of nuclear factor-κB-dependent gene expression and apoptosis

Rudi Beyaert, Karen Heyninck, Sofie Van Huffel

Journal:

Biochemical Pharmacology

Year:

2000

Language:

english

File:

PDF, 299 KB

english, 2000

10

Nuclear factor-kappa B plays a central role in tumour necrosis factor-mediated liver disease

Karen Heyninck, Andy Wullaert, Rudi Beyaert

Journal:

Biochemical Pharmacology

Year:

2003

Language:

english

File:

PDF, 132 KB

english, 2003

11

A20 Inhibits NF-κB Activation Independently of Binding to 14-3-3 Proteins

Dirk De Valck, Karen Heyninck, Wim Van Criekinge, Peter Vandenabeele, Walter Fiers, Rudi Beyaert

Journal:

Biochemical and Biophysical Research Communications

Year:

1997

Language:

english

File:

PDF, 606 KB

english, 1997

12

Crosstalk between NF-κB-Activating and Apoptosis-Inducing Proteins of the TNF-Receptor Complex

Karen Heyninck, Rudi Beyaert

Journal:

Molecular Cell Biology Research Communications

Year:

2001

Language:

english

File:

PDF, 76 KB

english, 2001

13

A20, an inhibitor of cell death, self-associates by its zinc finger domain

Dirk De Valck, Karen Heyninck, Wim Van Criekinge, Roland Contreras, Rudi Beyaert, Walter Fiers

Journal:

Year:

1996

Language:

english

File:

PDF, 461 KB

english, 1996

14

Ubiquitin: tool and target for intracellular NF-κB inhibitors

Andy Wullaert, Karen Heyninck, Sophie Janssens, Rudi Beyaert

Journal:

Trends in Immunology

Year:

2006

Language:

english

File:

PDF, 1.09 MB

english, 2006

15

Functional redundancy of the zinc fingers of A20 for inhibition of NF-κB activation and protein–protein interactions

Marco Klinkenberg, Sofie Van Huffel, Karen Heyninck, Rudi Beyaert

Journal:

Year:

2001

Language:

english

File:

PDF, 297 KB

english, 2001

16

Structure–function analysis of the A20-binding inhibitor of NF-κB activation, ABIN-1

Karen Heyninck, Marja M Kreike, Rudi Beyaert

Journal:

Year:

2003

Language:

english

File:

PDF, 568 KB

english, 2003

17

The cytokine-inducible zinc finger protein A20 inhibits IL-1-induced NF-κB activation at the level of TRAF6

Karen Heyninck, Rudi Beyaert

Journal:

Year:

1999

Language:

english

File:

PDF, 118 KB

english, 1999

18

Molecular insight in the multifunctional activities of Withaferin A

Wim Vanden Berghe, Linde Sabbe, Mary Kaileh, Guy Haegeman, Karen Heyninck

Journal:

Biochemical Pharmacology

Year:

2012

Language:

english

File:

PDF, 664 KB

english, 2012

19

The serotonin 5-HT7receptors: two decades of research

Gellynck, Evelien, Heyninck, Karen, Andressen, Kjetil W., Haegeman, Guy, Levy, Finn Olav, Vanhoenacker, Peter, Van Craenenbroeck, Kathleen

Journal:

Experimental Brain Research

Year:

2013

Language:

english

File:

PDF, 406 KB

english, 2013

20

Flavanols Modulate the Transcription of Genes Involved in Cardiovascular Pathology with Heterogenic Changes of Their DNA Methylation State: FLAVIOLA Associated

Weseler, Antje R., Milenkovic, Dragan, Vanden Berghe, Wim, Ruijters, Erik J.B., Heyninck, Karen, Fuks, François, Haegeman, Guy, Haenen, Guido R.M.M., Bast, Aalt

Journal:

Free Radical Biology and Medicine

Year:

2012

Language:

english

File:

PDF, 228 KB

english, 2012

21

The role of serine- and metalloproteases in Nasonia vitripennis venom in cell death related processes towards a Spodoptera frugiperda Sf21 cell line

Formesyn, Ellen M., Heyninck, Karen, de Graaf, Dirk C.

Journal:

Journal of Insect Physiology

Year:

2013

Language:

english

File:

PDF, 1.93 MB

english, 2013

22

The Zinc Finger Protein A20 Inhibits TNF-Induced NF-κB-Dependent Gene Expression by Interfering with an RIP- or TRAF2-Mediated Transactivation Signal and Directly Binds to a Novel NF-κB-Inhibiting Protein ABIN

Karen Heyninck, Dirk De Valck, Wim Vanden Berghe, Wim Van Criekinge, Roland Contreras, Walter Fiers, Guy Haegeman and Rudi Beyaert

Journal:

The Journal of Cell Biology

Year:

1999

Language:

english

File:

PDF, 1.12 MB

english, 1999

23

FLAVANOLS: WHAT DO WE KNOW ABOUT THEIR MECHANISMS OF ACTION?

Bast, Aalt, Claude, Sylvain, Haegeman, Guy, Haenen, Guido R.M.M., Heiss, Christian, Heyninck, Karen, Merx, Marc, Milenkovic, Dragan, Morand, Christine, Ruijters, Erik J.B., Vanden Berghe, Wim, Weseler

Journal:

Free Radical Biology and Medicine

Year:

2012

File:

PDF, 300 KB

2012

24

Withaferin A inhibits NF-kappaB activation by targeting cysteine 179 in IKKβ

Heyninck, Karen, Lahtela-Kakkonen, Maija, Van der Veken, Pieter, Haegeman, Guy, Vanden Berghe, Wim

Journal:

Biochemical Pharmacology

Year:

2014

Language:

english

File:

PDF, 1.33 MB

english, 2014

25

Hepatic Tumor Necrosis Factor Signaling and Nuclear Factor-κB: Effects on Liver Homeostasis and Beyond

Wullaert, Andy, van Loo, Geert, Heyninck, Karen, Beyaert, Rudi

Journal:

Endocrine Reviews

Year:

2007

Language:

english

File:

PDF, 1.10 MB

english, 2007

26

Withaferin A induces heme oxygenase (HO-1) expression in endothelial cells via activation of the Keap1/Nrf2 pathway

Heyninck, Karen, Sabbe, Linde, Chirumamilla, Chandra Sekhar, Szic, Katarzyna Szarc vel, Veken, Pieter Vander, Lemmens, Kristien J.A., Lahtela-Kakkonen, Maija, Naulaerts, Stefan, Op de Beeck, Ken, Lauk

Journal:

Biochemical Pharmacology

Year:

2016

Language:

english

File:

PDF, 2.32 MB

english, 2016

27

Isolation and characterization of two novel A20-like proteins

EVANS, Paul C., TAYLOR, Ellen R., COADWELL, John, HEYNINCK, Karen, BEYAERT, Rudi, KILSHAW, Peter J.

Journal:

Biochemical Journal

Year:

2001

Language:

english

File:

PDF, 275 KB

english, 2001

28

TNFα- and IKKβ-mediated TANK/I-TRAF phosphorylation: implications for interaction with NEMO/IKKγ and NF-κB activation

Bonif, Marianne, Meuwis, Marie-Alice, Close, Pierre, Benoit, Valérie, Heyninck, Karen, Chapelle, Jean-Paul, Bours, Vincent, Merville, Marie-Paule, Piette, Jacques, Beyaert, Rudi, Chariot, Alain

Journal:

Biochemical Journal

Year:

2006

Language:

english

File:

PDF, 552 KB

english, 2006

29

Isolation and characterization of two novel A20-like proteins

EVANS, Paul C., TAYLOR, Ellen R., COADWELL, John, HEYNINCK, Karen, BEYAERT, Rudi, KILSHAW, Peter J.

Journal:

Biochemical Journal

Year:

2001

Language:

english

File:

PDF, 275 KB

english, 2001

30

Identification of differentially methylated BRCA1 and CRISP2 DNA regions as blood surrogate markers for cardiovascular disease

Istas, Geoffrey, Declerck, Ken, Pudenz, Maria, Szic, Katarzyna Szarc vel, Lendinez-Tortajada, Veronica, Leon-Latre, Montserrat, Heyninck, Karen, Haegeman, Guy, Casasnovas, Jose A., Tellez-Plaza, Maria

Journal:

Scientific Reports

Year:

2017

Language:

english

File:

PDF, 2.12 MB

english, 2017

31

How the Venom from the Ectoparasitoid Wasp Nasonia vitripennis Exhibits Anti-Inflammatory Properties on Mammalian Cell Lines

Danneels, Ellen L., Gerlo, Sarah, Heyninck, Karen, Van Craenenbroeck, Kathleen, De Bosscher, Karolien, Haegeman, Guy, de Graaf, Dirk C., Pizzo, Salvatore V.

Journal:

Year:

2014

Language:

english

File:

PDF, 1.55 MB

english, 2014

32

Immunomodulatory effects of 17-O-acetylacuminolide in RAW264.7 cells and HUVECs: involvement of MAPK and NF-κB pathways

Mustafa, Mohammad Rais, Achoui, Mouna, Heyninck, Karen, Looi, Chung Yeng, Mohd, Mustafa Ali, Haegeman, Guy

Journal:

Drug Design Development and Therapy

Year:

2014

Language:

english

File:

PDF, 4.24 MB

english, 2014